You can find two examples of using @daml/ledger outside of React in @gyorgybalazsi’s blogpost on using it with Elm and @anthony’s o_beer app which uses Vue.js.
That said while both Vue.js and Elm are perfectly valid options, I don’t think any of them are fundamentally easier than React if you don’t have prior experience with any of them. And on the other hand, chosing something other than React drastically reduces the number of Daml apps you can use as a reference so you might end up making your life harder not easier.